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Ammonia is released as a result of the transformation of glutamine into glutamate [78, 79]

Yet, under regulation of the ISR pathway an ATF4-mediated upregulation of NRF2 via CHAC1 activity was shown as well ( 2.3.1 The dual role of CHAC1 in cancer CHAC1s function in cancer is complex and highly context-dependent

Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS lost trial